Purine metabolism pdf
Purine and Pyrimidine Nucleotide Synthesis and Metabolism 5 of 20. Salvage synthesis of purine nucleotides. The salvage cycle interconverts purine bases, nucleosides. and nucleotides released as byproducts of cellular. metabolism or from the catabolism of nucleic acids or. nucleotide cofactors.Nucleotide Metabolism. Purine de novo Metabolism Summary. Nucleotides are the Building Blocks of Nucleic Acids. Nucleotide Metabolism Proceeds Through de novo and Salvage Pathways. purine metabolism pdf
Defects in some of the enzymes of purine metabolism are known to be associated with specific clinical disorders (Table 187. 1). Although purines are essential in all cells of the body, the clinical manifestations of these disorders often suggest the nervous system to be more seriously affected than other organs.
Purines and Pyrimidines. Purines and Pyrimidines have an essential role in the production of high energy. compounds (e. g. ATP), building blocks for DNA, RNA, as signalling molecules. (e. g. cAMP) and as intermediates of glycosylation reactions (e. g. UDPglucose). ! 1! Purine Metabolism; de novo synthesis and salvage pathway, 201 5, Companion to Lecture Notes. Slide 2 For each mole of glucose 6 PO 4 metabolized to ribulose 5 PO 4, 2 moles of NADPH are produced. 6Phosphogluconate dh is not only purine metabolism pdf Purines which also contribute to modulate energy metabolism and signal transduction, are structural components of some coenzymes and have been shown to play important roles in the physiology of
Purine metabolism congenital diseases may compromise the following enzymes: (1) purine synthesis de novoPRS, adenylatosuccinate lyase, and ATIC; (2) salvage purine synthesisHPRT and APRT; and (3) purine interconversion and degradation pathwayXOR, PNP, ADA, adenylate kinase, and myoadenilate deaminase. On the other hand, certain drugs may also inhibit enzymes of the purine purine metabolism pdf Disorders of Nucleotide Metabolism: Hyperuricemia and Gout. Gout (also called urate crystal deposition disease) is a condition characterized. by hyperuricemia high levels of uric acid. the deposition of monosodium urate and uric acid crystals in tissues as a result of. Pyrimidine Metabolism. Pyrimidine Metabolism. Although both pyrimidines and purines are components in nucleic acids, they are made in different ways. Likewise, the products of pyrimidine degradation are more watersoluble than are the products of purine degradation. Amidophosphoribosyl transferase displays molecular heterogeneity; it exists in a small form with molecular weight of 133, 000 and large form of 270, 000 molecular weight. The smaller molecule is the active one and is converted to the large form in vitro by incubation of the PURINE METABOLISM AND GOUT 205 enzyme with purine nucleotides. Purine salvage pathway Liver is the major site of synthesis. It contains phosphoribosylation by PRPP of free purine to form purine mononucleotide such asRating: 4.74 / Views: 508